|
Symbol Name ID |
C3
complement component 3 MGI:88227 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Leukocytosis |
Leukopenia |
Pericarditis |
Lymphadenopathy |
Abnormality of the spleen |
Splenic infarction |
Splenomegaly |
Recurrent tonsillitis |
Lupus nephritis |
Membranoproliferative glomerulonephritis |
Nephritis |
Abnormality of the immune system |
Discoid lupus rash |
Malar rash |
Osteomyelitis |
Recurrent pneumonia |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Systemic lupus erythematosus |
Asthma |
Recurrent infections |
Recurrent bacterial infections |
| Disease(s) Associated with C3 | |||||||||||||||||||||||||||||||
| asthma | |||||||||||||||||||||||||||||||
| complement component 3 deficiency | |||||||||||||||||||||||||||||||
| paroxysmal nocturnal hemoglobinuria | |||||||||||||||||||||||||||||||
| sickle cell anemia | |||||||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | immune system phenotype |
decreased susceptibility to autoimmune hemolytic anemia |
decreased mast cell number |
decreased neutrophil cell number |
abnormal neutrophil morphology |
decreased osteoclast cell number |
abnormal spleen germinal center morphology |
decreased spleen germinal center number |
decreased spleen germinal center size |
abnormal mast cell physiology |
decreased circulating interleukin-6 level |
decreased circulating tumor necrosis factor level |
abnormal tumor necrosis factor level |
abnormal immune system morphology |
abnormal immune system physiology |
abnormal cell-mediated immunity |
abnormal humoral immune response |
impaired complement alternative pathway |
decreased susceptibility to induced arthritis |
abnormal inflammatory response |
brain inflammation |
liver inflammation |
glomerulonephritis |
increased susceptibility to bacterial infection |
increased susceptibility to bacterial infection induced morbidity/mortality |
decreased susceptibility to Coronaviridae infection |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||
| C3tm1Crr/C3tm1Crr | * | ||||||||||||||||||||||||||
| C3tm1Hrc/C3tm1Hrc | |||||||||||||||||||||||||||
| C3tm1Pkna/C3tm1Pkna | |||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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